Pregnancy and Thrombophilia
نویسنده
چکیده
Thrombophilic disorders encompass a diverse group of coagulation disorders that potentiate a predisposition for thrombotic events (e.g. deep vein thrombosis and pulmonary embolism). The term thrombophilia was coined in 1965 following a Norwegian familial study of venous thrombosis [1]. The entity of thrombophilia has also been described as a disorder in which there is abnormally, enhanced coagulation [2]. Amongst the known thrombophilia are antithrombin III deficiency, prothrombin G20210A gene mutation, protein S and protein C deficiency, activated protein C resistance and the antiphospholipid syndrome. Thrombophilia and its influence on pregnancy have been studied for the past 50 years. Both inherited and acquired thrombophilia have been associated with an increased risk of thrombo-embolism as well as an increased risk of pregnancy loss and adverse obstetric outcomes. This review aims to provide an overview and update on the influence of the various inherited and acquired thrombophilia in pregnancy.
منابع مشابه
Thrombophilia, Anticoagulant Therapy, and Pregnancy Outcome in Women with Poor Obstetric History
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